Preliminary Results of Noninvasive Ocular Rigidity in Diabetic Retinopathy Using Optical Coherence Tomography

The pathologic mechanism of diabetic retinopathy is directly related to the underlying hyperglycemia associated with diabetes. Hyperglycemia causes non-enzymatic cross-linking collagen fibrils which contributes mechanistically tissue stiffening. However, investigations on retinopathy-associated alteration in ocular biomechanics remain scarce, especially living human eyes. Ocular rigidity classically defined as a measure change intraocular pressure produced by volume. We recently implemented an approach for direct in-vivo non-invasive estimate using optical coherence tomography, allowing evaluation biomechanical behavior eyes retinopathy. Our preliminary results showed that exhibited higher and scleral stiffness compared normal controls, may possibly be attributed hyperglycemia-induced tissues. Knowledge changes will equip us new quantitative tools identify diagnostic markers